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Core B Publications 

Papers from the current funding period

Aleman M, Zhang R, Feng W, Qi L, Lopez JR, Crowe C, Dong Y, Cherednichenko G, Pessah IN. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. Molecular pharmacology. 2020;98(4):351-63. Epub 2020/08/09. doi: 10.1124/mol.120.119412. PubMed PMID: 32764093; PMCID: PMC7491310.

Anderson CG, Joshi G, Bair DA, Oriol C, He G, Parikh SJ, , Scow KM. Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. Chemosphere. 2017;181:160-7Epub 2017/04/25. doi: 10.1016/j.chemosphere.2017.04.035. PubMed PMID: 28437741 )

Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD. Development of potent inhibitors of the human microsomal epoxide hydrolase. European journal of medicinal chemistry. 2020;193:112206. Epub 2020/03/24. doi: 10.1016/j.ejmech.2020.112206. PubMed PMID: 32203787; PMCID: PMC7366823. (Project 1 and Core A)

Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. Journal of medicinal chemistry. 2018;61(8):3541-50. Epub 2018/04/04. doi: 10.1021/acs.jmedchem.7b01804. PubMed PMID: 29614224; PMCID: PMC5933862. (Project 5)

Brennan JC, Bassal A, He G, . Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor α and β for improved detection of estrogenic/antiestrogenic chemicals. Environmental toxicology and chemistry. 2016;35(1):91-100. Epub 2015/07/04. doi: 10.1002/etc.3146. PubMed PMID: 26139245; PMCID: PMC4772679.

Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, , Wang H, , Sharpless KB, Kelly JW. Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nature chemistry. 2020;12(10):906-13. Epub 2020/09/02. doi: 10.1038/s41557-020-0530-4. PubMed PMID: 32868886; PMCID: PMC7541551.

Burmistrov V, , D'Yachenko V, Karlov D, Butov GM, . Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorganic & medicinal chemistry letters. 2020;30(3):126908. Epub 2019/12/25. doi: 10.1016/j.bmcl.2019.126908. PubMed PMID: 31870649; PMCID: PMC6957307. 

Burmistrov V, , D'Yachenko V, Rybakov VB, Butov GM, . Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. Journal of fluorine chemistry. 2019;220:48-53. Epub 2020/03/07. doi: 10.1016/j.jfluchem.2019.02.005. PubMed PMID: 32132741; PMCID: PMC7055688. 

Burmistrov V, , Harris TR, Butov G, . Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorganic chemistry. 2018;76:510-27. Epub 2018/01/09. doi: 10.1016/j.bioorg.2017.12.024. PubMed PMID: 29310082; PMCID: PMC5837815. 

Burmistrov V, Morisseau C, Karlov D, Pitushkin D, Vernigora A, Rasskazova E, Butov GM, Hammock BD. Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry letters. 2020;30(18):127430. Epub 2020/08/01. doi: 10.1016/j.bmcl.2020.127430. PubMed PMID: 32736212; PMCID: Pmc7494652. (Project 5)

Burmistrov V, , Pitushkin D, Karlov D, Fayzullin RR, Butov GM, . Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry letters. 2018;28(13):2302-13. Epub 2018/05/29. doi: 10.1016/j.bmcl.2018.05.024. PubMed PMID: 29803731; PMCID: PMC6442743. 

Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cellular and molecular bioengineering. 2016;9(3):433-42. Epub 2016/11/01. doi: 10.1007/s12195-016-0449-4. PubMed PMID: 27795742; PMCID: PMC5079442.

Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Scientific reports. 2017;7(1):427. Epub 2017/03/30. doi: 10.1038/s41598-017-00447-7. PubMed PMID: 28348397; PMCID: PMC5428417.

Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Advanced functional materials. 2017;27(3). Epub 2017/06/20. doi: 10.1002/adfm.201604631. PubMed PMID: 28626362; PMCID: PMC5471629.

Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, Pérez B, Pérez C, Rodríguez-Franco MI, Leiva R, Osuna S, , , Vázquez-Carrera M, Vázquez S. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. Journal of medicinal chemistry. 2020;63(17):9237-57. doi: 10.1021/acs.jmedchem.0c00310. PubMed PMID: 32787085.

Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, , , Vázquez S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry. 2019;27(20):115078. Epub 2019/09/07. doi: 10.1016/j.bmc.2019.115078. PubMed PMID: 31488357; PMCID: PMC6892585.

Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, , Fangue NA, Connon RE. Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls. Archives of environmental contamination and toxicology. 2016;71(2):210-23. Epub 2016/05/09. doi: 10.1007/s00244-016-0282-8. PubMed PMID: 27155869. 

Croes K, Debaillie P, Van den Bril B, Staelens J, Vandermarken T, Van Langenhove K, , Leermakers M, Elskens M. Assessment of estrogenic activity in PM₁₀ air samples with the ERE-CALUX bioassay: Method optimization and implementation at an urban location in Flanders (Belgium). Chemosphere. 2016;144:392-8. Epub 2015/09/19. doi: 10.1016/j.chemosphere.2015.09.020. PubMed PMID: 26383266.

Croes K, Van den Heuvel R, Van den Bril B, Staelens J, , Van Langenhove K, Vandermarken T, Elskens M. Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. Environmental research. 2016;150:66-72. Epub 2016/06/04. doi: 10.1016/j.envres.2016.05.044. PubMed PMID: 27257826.

de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International journal of biological macromolecules. 2019;129:653-8. Epub 2019/02/17. doi: 10.1016/j.ijbiomac.2019.02.070. PubMed PMID: 30771398; PMCID: PMC6447457. (Project 5)

de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular biology reports. 2019;46(1):371-9. Epub 2018/11/15. doi: 10.1007/s11033-018-4481-4. PubMed PMID: 30426381; PMCID: PMC6426676. (Project 5)

Denison MS, Faber SC. And Now for Something Completely Different: Diversity in Ligand-Dependent Activation of Ah Receptor Responses. Current opinion in toxicology. 2017;2:124-31. Epub 2017/08/29. doi: 10.1016/j.cotox.2017.01.006. PubMed PMID: 28845473; PMCID: PMC5570615.

Duflot T, Moreau-Grangé L, Roche C, Iacob M, Wils J, Rémy-Jouet I, Cailleux AF, Leuillier M, Renet S, Li D, , Lamoureux F, Richard V, Prévost G, Joannidès R, Bellien J. Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. Cardiovascular diabetology. 2019;18(1):35. Epub 2019/03/20. doi: 10.1186/s12933-019-0843-z. PubMed PMID: 30885203; PMCID: PMC6423843. 

Faber SC, Giani Tagliabue S, Bonati L, Denison MS. The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor. International journal of molecular sciences. 2020;21(11). Epub 2020/06/13. doi: 10.3390/ijms21114111. PubMed PMID: 32526934; PMCID: PMC7312509.

Faber SC, Soshilov AA, Giani Tagliabue S, Bonati L, Denison MS. Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist. International journal of molecular sciences. 2018;19(9). Epub 2018/09/12. doi: 10.3390/ijms19092692. PubMed PMID: 30201897; PMCID: PMC6165432.

Feng W, Zheng J, Robin G, Dong Y, Ichikawa M, Inoue Y, Mori T, Nakano T, . Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks. Environmental science & technology. 2017;51(24):14406-16. Epub 2017/11/14. doi: 10.1021/acs.est.7b04446. PubMed PMID: 29131945; PMCID: PMC6251309.

Guo W, Van Langenhove K, , Baeyens W, Elskens M, Gao Y. Estrogenic Activity Measurements in Water Using Diffusive Gradients in Thin-Film Coupled with an Estrogen Bioassay2017;89(24):13357-64. doi: 10.1021/acs.analchem.7b03537. PubMed PMID: 29151339.

Haedrich J, Stumpf C, . Rapid extraction of total lipids and lipophilic POPs from all EU-regulated foods of animal origin: Smedes’ method revisited and enhanced. Environmental Sciences Europe. 2020;32(1):118. doi: 10.1186/s12302-020-00396-5.

Hayashi A, . Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells. Toxicology in vitro : an international journal published in association with BIBRA. 2020;66:104873. Epub 2020/04/26. doi: 10.1016/j.tiv.2020.104873. PubMed PMID: 32333947; PMCID: PMC7260106.

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, , Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, , , Proschak E. Computer-Aided Selective Optimization of Side Activities of Talinolol. ACS medicinal chemistry letters. 2019;10(6):899-903. Epub 2019/06/22. doi: 10.1021/acsmedchemlett.9b00075. PubMed PMID: 31223445; PMCID: Pmc6580380. 

Hill T, 3rd, Rice RH. DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicology in vitro : an international journal published in association with BIBRA. 2018;46:257-64. Epub 2017/10/17. doi: 10.1016/j.tiv.2017.10.010. PubMed PMID: 29031483; PMCID: PMC5683910.

Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, . An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors. Toxicological sciences : an official journal of the Society of Toxicology. 2017;155(1):170-81. Epub 2016/09/24. doi: 10.1093/toxsci/kfw189. PubMed PMID: 27655348; PMCID: PMC5216651. 

Holland EB, Goldstone JV, , Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquatic toxicology (Amsterdam, Netherlands). 2017;192:105-15. Epub 2017/09/25. doi: 10.1016/j.aquatox.2017.09.002. PubMed PMID: 28942070; PMCID: PMC5662517.

Joshi G, Schmidt R, Scow KM, , Hristova KR. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology (Reading, England). 2016;162(9):1563-71. Epub 2016/07/28. doi: 10.1099/mic.0.000338. PubMed PMID: 27450417; PMCID: PMC5903209.

Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, , , Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain, behavior, and immunity. 2019;81:545-59. Epub 2019/07/22. doi: 10.1016/j.bbi.2019.07.015. PubMed PMID: 31325531; PMCID: PMC7155744. 

Khedidji S, Croes K, Yassaa N, Ladji R, , Baeyens W, Elskens M. Assessment of dioxin-like activity in PM(10) air samples from an industrial location in Algeria, using the DRE-CALUX bioassay2017;24(13):11868-77. doi: 10.1007/s11356-015-5841-4. PubMed PMID: 26611627.

Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C. Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. Journal of medicinal chemistry. 2016;59(10):4790-9. Epub 2016/04/28. doi: 10.1021/acs.jmedchem.6b00173. PubMed PMID: 27120257; PMCID: PMC4957648.

Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PloS one. 2017;12(5):e0176571. Epub 2017/05/05. doi: 10.1371/journal.pone.0176571. PubMed PMID: 28472063; PMCID: PMC5417501 

Kodani SD, Barthélemy M, Kamita SG, Hammock BD, Morisseau C. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Analytical biochemistry. 2017;539:81-9. Epub 2017/10/22. doi: 10.1016/j.ab.2017.10.014. PubMed PMID: 29054529; PMCID: PMC5696082.

Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & medicinal chemistry letters. 2018;28(4):762-8. Epub 2018/01/26. doi: 10.1016/j.bmcl.2018.01.003. PubMed PMID: 29366648; PMCID: PMC5837813. (Project 5)

Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, , , Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. Journal of medicinal chemistry. 2019;62(18):8443-60. Epub 2019/08/23. doi: 10.1021/acs.jmedchem.9b00445. PubMed PMID: 31436984; PMCID: PMC7262789. 

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. The Journal of cell biology. 2015;211(5):1057-75. Epub 2015/12/09. doi: 10.1083/jcb.201404147. PubMed PMID: 26644517; PMCID: PMC4674273.

Lee KSS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner K, Hammock BD. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorganic & medicinal chemistry. 2020;28(22):115735. Epub 2020/10/03. doi: 10.1016/j.bmc.2020.115735. PubMed PMID: 33007552. (Core A & Project 5)

Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways. ACS central science. 2019;5(9):1614-24. Epub 2019/10/02. doi: 10.1021/acscentsci.9b00770. PubMed PMID: 31572788; PMCID: PMC6764161 California holds patents on the sEH inhibitors to treat disease. Some of these patents have been licensed by EicOsis L.L.C., a startup company advancing sEH inhibitors as potential therapeutics. BDH is cofounder and JY and KW are employees of EicOsis L.L.C. (Core A & Project 5)

Li D, Cui Y, Morisseau C, Gee SJ, Bever CS, Liu X, Wu J, Hammock BD, Ying Y. Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP? Analytical chemistry. 2017;89(11):6248-56. Epub 2017/05/04. doi: 10.1021/acs.analchem.7b01247. PubMed PMID: 28460522; PMCID: PMC5611449. (Projects 3 & 5)

Li D, Cui Y, Morisseau C, Wagner KM, Cho YS, Hammock BD. Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer. Analytical chemistry. 2020;92(17):11654-63. Epub 2020/08/14. doi: 10.1021/acs.analchem.0c01511. PubMed PMID: 32786492. (Projects 3 & 5)

Li D, Morisseau C, McReynolds CB, Duflot T, Bellien J, Nagra RM, Taha AY, Hammock BD. Development of Improved Double-Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detection in Peripheral Blood Mononuclear Cells of Diabetic Patients and the Prefrontal Cortex of Multiple Sclerosis Patients. Analytical chemistry. 2020;92(10):7334-42. doi: 10.1021/acs.analchem.0c01115. PubMed PMID: 32253910. (Projects 2, 3 & 5)

Li X, Holland EB, Feng W, Zheng J, Dong Y, , Duffel MW, Robertson LW, Lehmler HJ. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environmental science and pollution research international. 2018;25(17):16508-21. Epub 2018/01/13. doi: 10.1007/s11356-017-1162-0. PubMed PMID: 29322390; PMCID: PMC6015536.

Liu JY, , Huang H, . Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. Journal of ethnopharmacology. 2016;194:475-82. Epub 2016/10/06. doi: 10.1016/j.jep.2016.09.044. PubMed PMID: 27702689; PMCID: PMC5584568. 

Liu JY, , , Lango J, Hwang SH, Watanabe T, Kim IH, . In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochemical pharmacology. 2015;98(4):718-31. Epub 2015/10/24. doi: 10.1016/j.bcp.2015.10.013. PubMed PMID: 26494425; PMCID: PMC4656071. 

McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in pharmacology. 2019;10:533. Epub 2019/06/20. doi: 10.3389/fphar.2019.00533. PubMed PMID: 31214021; PMCID: PMC6554663. (Project 5 & Core A)

Mehinto AC, VanDervort DR, Lao W, He G, , Vliet SM, Volz DC, Mazor RD, Maruya KA. High throughput in vitro and in vivo screening of inland waters of Southern California. Environmental science Processes & impacts. 2017;19(9):1142-9. Epub 2017/06/15. doi: 10.1039/c7em00170c. PubMed PMID: 28612856.

Mexia N, Koutrakis S, He G, Skaltsounis AL, , Magiatis P. A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy. Chemical research in toxicology. 2019;32(11):2238-49. Epub 2019/10/28. doi: 10.1021/acs.chemrestox.9b00270. PubMed PMID: 31647221.

Middleton BR, Talaugon S, Young TM, Wong L, Fluharty S, Reed K, Cosby C, Myers R, 2nd. Bi-Directional Learning: Identifying Contaminants on the Yurok Indian Reservation. International journal of environmental research and public health. 2019;16(19). Epub 2019/09/25. doi: 10.3390/ijerph16193513. PubMed PMID: 31547171; PMCID: PMC6801823. (Project 1 & Core C)

Mishra M, , Gunaseelan A, , , . Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis. 2019;40(12-13):1731-9. Epub 2019/04/26. doi: 10.1002/elps.201900059. PubMed PMID: 31021001; PMCID: PMC7036291. 

Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, , , , Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. American journal of physiology Lung cellular and molecular physiology. 2017;313(2):L252-l66. Epub 2017/05/06. doi: 10.1152/ajplung.00453.2016. PubMed PMID: 28473326; PMCID: PMC5582936. 

Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, , Halim M, , , Deng SX. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins & other lipid mediators. 2018;136:90-5. Epub 2018/03/24. doi: 10.1016/j.prostaglandins.2018.02.004. PubMed PMID: 29567338; PMCID: PMC5970965. 

Pessah IN, Lein PJ, Seegal RF, Sagiv SK. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta neuropathologica. 2019;138(3):363-87. Epub 2019/04/13. doi: 10.1007/s00401-019-01978-1. PubMed PMID: 30976975; PMCID: PMC6708608.

Pessah IN, Truong K. Additional Safety Assessments Needed for Diamide Insecticides. Toxicological sciences : an official journal of the Society of Toxicology. 2019;171(2):282. Epub 2019/03/05. doi: 10.1093/toxsci/kfz062. PubMed PMID: 30830166; PMCID: Pmc6760268.

Philippat C, Barkoski J, , Elms B, Barr DB, Ozonoff S, Bennett DH, Hertz-Picciotto I. Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non-typical development at 3 years in a high-risk cohort. International journal of hygiene and environmental health. 2018;221(3):548-55. Epub 2018/02/27. doi: 10.1016/j.ijheh.2018.02.004. PubMed PMID: 29478806; PMCID: Pmc6397031.

Phillips MA, Cánovas A, Wu PW, Islas-Trejo A, Medrano JF, Rice RH. Parallel responses of human epidermal keratinocytes to inorganic SbIII and AsIII. Environmental chemistry (Collingwood, Vic). 2016;13(6):963-70. Epub 2016/01/01. doi: 10.1071/en16019. PubMed PMID: 28713220; PMCID: PMC5507681.

Rice RH, , Ishitsuka Y, Salemi M, Phinney BS, , Roop DR. Proteomic Analysis of Loricrin Knockout Mouse Epidermis. Journal of proteome research. 2016;15(8):2560-6. Epub 2016/07/16. doi: 10.1021/acs.jproteome.6b00108. PubMed PMID: 27418529.

Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, , De Waard M. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(17):E2460-8. Epub 2016/04/14. doi: 10.1073/pnas.1517342113. PubMed PMID: 27071086; PMCID: PMC4855579.

Shihadih DS, Harris TR, , Hwang SH, , Mavangira V, Hamamoto B, Guedes A, , . Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Frontiers in veterinary science. 2020;7:580. Epub 2020/10/03. doi: 10.3389/fvets.2020.00580. PubMed PMID: 33005645; PMCID: PMC7479175. 

Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. Journal of neuroinflammation. 2018;15(1):7. Epub 2018/01/08. doi: 10.1186/s12974-017-1050-z. PubMed PMID: 29306331; PMCID: PMC5756609.

Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 2015;338:59-68. Epub 2015/10/16. doi: 10.1016/j.tox.2015.10.002. PubMed PMID: 26463278; PMCID: PMC4658283. (U. of Iowa SRC)

Sun CP, Zhang J, Zhao WY, Yi J, Yan JK, Wang YL, , Liu ZB, , Ma XC. Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Bioorganic chemistry. 2020;96:103637. Epub 2020/02/08. doi: 10.1016/j.bioorg.2020.103637. PubMed PMID: 32032849; PMCID: PMC7233170. 

Truong KM, Cherednichenko G, . Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1. Toxicological sciences : an official journal of the Society of Toxicology. 2019;170(2):509-24. Epub 2019/05/28. doi: 10.1093/toxsci/kfz120. PubMed PMID: 31127943; PMCID: PMC6657572.

Truong KM, Feng W, . Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2020;178(1):159-72. Epub 2020/09/08. doi: 10.1093/toxsci/kfaa139. PubMed PMID: 32894766.

Truong KM, . Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance. Toxicological sciences : an official journal of the Society of Toxicology. 2019;167(2):509-23. Epub 2018/10/18. doi: 10.1093/toxsci/kfy256. PubMed PMID: 30329129; PMCID: Pmc6358238.

Vandermarken T, De Galan S, Croes K, Van Langenhove K, Vercammen J, Sanctorum H, , Goeyens L, Elskens M, Baeyens W. Characterisation and implementation of the ERE-CALUX bioassay on indoor dust samples of kindergartens to assess estrogenic potencies. The Journal of steroid biochemistry and molecular biology. 2016;155(Pt B):182-9. Epub 2015/01/18. doi: 10.1016/j.jsbmb.2015.01.005. PubMed PMID: 25595043.

Vandermarken T, Gao Y, Baeyens W, , Croes K. Dioxins, furans and dioxin-like PCBs in sediment samples and suspended particulate matter from the Scheldt estuary and the North Sea Coast: Comparison of CALUX concentration levels in historical and recent samples. The Science of the total environment. 2018;626:109-16. Epub 2018/01/18. doi: 10.1016/j.scitotenv.2018.01.084. PubMed PMID: 29335165.

Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Analytica chimica acta. 2019;1057:106-13. Epub 2019/03/06. doi: 10.1016/j.aca.2018.12.060. PubMed PMID: 30832908; PMCID: PMC6426448. (Project 3, Dartmouth college SRC)

Wang Z, Fang Y, Teague J, Wong H, , , Rock DA, Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug metabolism and disposition: the biological fate of chemicals. 2017;45(7):712-20. Epub 2017/04/22. doi: 10.1124/dmd.117.075226. PubMed PMID: 28428366; PMCID: PMC5452678. 

Wilt S, , Le TNH, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, , , Pecic S. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorganic chemistry. 2020;103:104165. Epub 2020/09/07. doi: 10.1016/j.bioorg.2020.104165. PubMed PMID: 32891856; PMCID: Pmc7723751. 

Wu N, , , An G. Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase. The Journal of pharmacology and experimental therapeutics. 2020;374(1):223-32. Epub 2020/04/03. doi: 10.1124/jpet.120.265330. PubMed PMID: 32238455; PMCID: Pmc7318792.

Zhang Y, Hong G, , , Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. Journal of neurochemistry. 2017;140(5):814-25. Epub 2016/12/22. doi: 10.1111/jnc.13933. PubMed PMID: 28002622; PMCID: PMC5310989. 

Zheng J, Chen J, Zou X, Zhao F, Guo M, Wang H, Zhang T, Zhang C, Feng W, , Cao Z. Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca(2+) concentration. Neurotoxicology. 2019;70:112-21. Epub 2018/11/21. doi: 10.1016/j.neuro.2018.11.006. PubMed PMID: 30458186; PMCID: PMC6342622.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, . Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca(2+) Dynamics. Environmental science & technology. 2018;52(9):5469-78. Epub 2018/04/05. doi: 10.1021/acs.est.8b00512. PubMed PMID: 29617551; PMCID: PMC6195434.

Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, , Cao Z. Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors. Environmental health perspectives. 2019;127(6):67003. Epub 2019/06/06. doi: 10.1289/ehp4583. PubMed PMID: 31166131; PMCID: PMC6792378.

Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, . A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Analytica chimica acta. 2019;1058:155-65. Epub 2019/03/11. doi: 10.1016/j.aca.2019.01.023. PubMed PMID: 30851849; PMCID: PMC7198451.

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