Papers from the current funding period

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Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock BD, Mozaffarian D. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. Journal of lipid research. 2016;57(3):492-8. Epub 2016/01/11. doi: 10.1194/jlr.P062398. PubMed PMID: 26749073; PMCID: PMC4766998. (Project 5) 

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An G, Lee KSS, Yang J, Hammock BD. Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors. Journal of clinical pharmacology. 2020. Epub 2020/10/21. doi: 10.1002/jcph.1763. PubMed PMID: 33078430. (Project 5) 

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Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Organic & biomolecular chemistry. 2017;15(20):4308-13. Epub 2017/05/05. doi: 10.1039/c7ob00789b. PubMed PMID: 28470279; PMCID: PMC5527127.

 

Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. PloS one. 2015;10(12):e0144996. Epub 2015/12/18. doi: 10.1371/journal.pone.0144996. PubMed PMID: 26672987; PMCID: PMC4681469. (Project 5) 

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Bever CS, Rand AA, Nording M, Taft D, Kalanetra KM, Mills DA, Breck MA, Smilowitz JT, German JB, Hammock BD. Effects of triclosan in breast milk on the infant fecal microbiome. Chemosphere. 2018;203:467-73. Epub 2018/04/11. doi: 10.1016/j.chemosphere.2018.03.186. PubMed PMID: 29635158; PMCID: PMC5915298. (Project 3) 

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Cinelli MA, Yang J, Scharmen A, Woodman J, Karchalla LM, Lee KSS. Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids. Journal of lipid research. 2018;59(11):2237-52. Epub 2018/09/14. doi: 10.1194/jlr.D089136. PubMed PMID: 30209076; PMCID: PMC6210906. 

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Cui X, Vasylieva N, Shen D, Barnych B, Yang J, He Q, Jiang Z, Zhao S, Hammock BD. Biotinylated single-chain variable fragment-based enzyme-linked immunosorbent assay for glycocholic acid. The Analyst. 2018;143(9):2057-65. Epub 2018/04/10. doi: 10.1039/c7an02024d. PubMed PMID: 29629470; PMCID: PMC6449042. (Project 3) 

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Cui X, Vasylieva N, Wu P, Barnych B, Yang J, Shen D, He Q, Gee SJ, Zhao S, Hammock BD. Development of an Indirect Competitive Enzyme-Linked Immunosorbent Assay for Glycocholic Acid Based on Chicken Single-Chain Variable Fragment Antibodies. Analytical chemistry. 2017;89(20):11091-7. Epub 2017/09/26. doi: 10.1021/acs.analchem.7b03190. PubMed PMID: 28942640; PMCID: PMC6459402. (Project 3)  

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Deng BQ, Luo Y, Kang X, Li CB, Morisseau C, Yang J, Lee KSS, Huang J, Hu DY, Wu MY, Peng A, Hammock BD, Liu JY. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(47):12608-13. Epub 2017/11/08. doi: 10.1073/pnas.1705615114. PubMed PMID: 29109264; PMCID: PMC5703276. 

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Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver. Frontiers in pharmacology. 2019;10:580. Epub 2019/06/14. doi: 10.3389/fphar.2019.00580. PubMed PMID: 31191316; PMCID: Pmc6548860. (Project 5) 

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Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Frontiers in pharmacology. 2019;10:1118. Epub 2019/10/16. doi: 10.3389/fphar.2019.01118. PubMed PMID: 31611798; PMCID: Pmc6777353. 

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Edin ML, Lih FB, Hammock BD, Thomson S, Zeldin DC, Bishop-Bailey D. Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids. Cells. 2020;9(5). Epub 2020/05/06. doi: 10.3390/cells9051096. PubMed PMID: 32365470; PMCID: PMC7290345. (Project 5) 

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Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP. Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus. Frontiers in microbiology. 2017;8:831. Epub 2017/05/26. doi: 10.3389/fmicb.2017.00831. PubMed PMID: 28536571; PMCID: PMC5422543. 

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Fishbein A, Wang W, Yang H, Yang J, Hallisey VM, Deng J, Verheul SML, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(35):21576-87. Epub 2020/08/18. doi: 10.1073/pnas.2007412117. PubMed PMID: 32801214; PMCID: PMC7474612. (Project 5) 

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Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(1):136-41. Epub 2016/12/17. doi: 10.1073/pnas.1610242114. PubMed PMID: 27980032; PMCID: Pmc5224368. (Project 5 and Dartmouth College SRC) 

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Gao Q, Jiang H, Tang F, Cao HQ, Wu XW, Qi FF, Sun J, Yang J. Evaluation of the bitter components of bamboo shoots using a metabolomics approach. Food & function. 2019;10(1):90-8. Epub 2018/12/19. doi: 10.1039/c8fo01820k. PubMed PMID: 30560250. 

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Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(5):1698-703. Epub 2019/01/17. doi: 10.1073/pnas.1803999116. PubMed PMID: 30647111; PMCID: PMC6358686. (Project 5) 

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Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicology and applied pharmacology. 2015;289(3):419-27. Epub 2015/11/03. doi: 10.1016/j.taap.2015.10.018. PubMed PMID: 26522832; PMCID: PMC4666679. (Project 5) 

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Goswami SK, Rand AA, Wan D, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang GY, Hammock BD. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life sciences. 2017;180:114-22. Epub 2017/05/20. doi: 10.1016/j.lfs.2017.05.018. PubMed PMID: 28522175; PMCID: PMC5659729. (Project 5) 

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Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD. Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers. The Journal of pharmacology and experimental therapeutics. 2016;357(3):529-36. Epub 2016/03/19. doi: 10.1124/jpet.116.232108. PubMed PMID: 26989141; PMCID: PMC4885505. (Project 5) 

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Griñán-Ferré C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Pérez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vázquez S, Pallàs M, Galdeano C. Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2020. Epub 2020/06/04. doi: 10.1007/s13311-020-00854-1. PubMed PMID: 32488482. (Project 5) 

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Guedes A, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine veterinary journal. 2017;49(3):345-51. Epub 2016/06/25. doi: 10.1111/evj.12603. PubMed PMID: 27338788; PMCID: PMC5580818. (Project 5) 

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Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. Journal of veterinary pharmacology and therapeutics. 2018;41(2):230-8. Epub 2017/10/27. doi: 10.1111/jvp.12463. PubMed PMID: 29067696; PMCID: PMC5920688. (Project 5) 

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Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. Molecular pharmacology. 2018;94(2):834-41. Epub 2018/05/31. doi: 10.1124/mol.118.111831. PubMed PMID: 29844231; PMCID: PMC6022802. (Project 5) 

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Harris TR, Kodani S, Yang J, Imai DM, Hammock BD. An ω-3-enriched diet alone does not attenuate CCl(4)-induced hepatic fibrosis. The Journal of nutritional biochemistry. 2016;38:93-101. Epub 2016/10/13. doi: 10.1016/j.jnutbio.2016.08.010. PubMed PMID: 27732914; PMCID: PMC5102762. (Project 5) 

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Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY. Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time. Journal of lipid research. 2019;60(3):671-82. Epub 2018/11/23. doi: 10.1194/jlr.D084228. PubMed PMID: 30463986; PMCID: PMC6399504. 

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Hennebelle M, Otoki Y, Yang J, Hammock BD, Levitt AJ, Taha AY, Swardfager W. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry research. 2017;252:94-101. Epub 2017/03/05. doi: 10.1016/j.psychres.2017.02.056. PubMed PMID: 28259037; PMCID: PMC5611448. 

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Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KSS, Hammock BD, Zhang L, Bazinet RP, Taha AY. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Scientific reports. 2017;7(1):4342. Epub 2017/07/01. doi: 10.1038/s41598-017-02914-7. PubMed PMID: 28659576; PMCID: PMC5489485. 

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Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochimica et biophysica acta Molecular basis of disease. 2017;1863(6):1382-91. Epub 2017/02/12. doi: 10.1016/j.bbadis.2017.02.004. PubMed PMID: 28185955; PMCID: PMC5608514. 

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Huo J, Barnych B, Li Z, Wan D, Li D, Vasylieva N, Knezevic SZ, Osipitan OA, Scott JE, Zhang J, Hammock BD. Hapten Synthesis, Antibody Development, and a Highly Sensitive Indirect Competitive Chemiluminescent Enzyme Immunoassay for Detection of Dicamba. Journal of agricultural and food chemistry. 2019;67(20):5711-9. Epub 2019/05/02. doi: 10.1021/acs.jafc.8b07134. PubMed PMID: 31042038; PMCID: PMC6873229. (Project 3) 

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Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD. Development of a Highly Sensitive Direct Competitive Fluorescence Enzyme Immunoassay Based on a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of 3-Phenoxybenzoic Acid in Urine. Journal of agricultural and food chemistry. 2018;66(43):11284-90. Epub 2018/10/09. doi: 10.1021/acs.jafc.8b04521. PubMed PMID: 30293433; PMCID: PMC6442738. (Project 3) 

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Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorganic & medicinal chemistry letters. 2017;27(3):620-5. Epub 2016/12/28. doi: 10.1016/j.bmcl.2016.12.002. PubMed PMID: 28025003; PMCID: PMC5584617. (Project 5) 

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Kim J, Ulu A, Wan D, Yang J, Hammock BD, Weiss RH. Addition of DHA Synergistically Enhances the Efficacy of Regorafenib for Kidney Cancer Therapy. Molecular cancer therapeutics. 2016;15(5):890-8. Epub 2016/02/28. doi: 10.1158/1535-7163.mct-15-0847. PubMed PMID: 26921392; PMCID: PMC4873345. (Project 5) 

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Knuth MM, Mahapatra D, Jima D, Wan D, Hammock BD, Law M, Kullman SW. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific reports. 2020;10(1):16032. Epub 2020/10/01. doi: 10.1038/s41598-020-72622-2. PubMed PMID: 32994480; PMCID: PMC7524799. (Project 5) 

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Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS omega. 2018;3(10):14076-86. Epub 2018/11/10. doi: 10.1021/acsomega.8b01625. PubMed PMID: 30411058; PMCID: PMC6210075 authors on a patent own by the University of California for compounds presented in this text (WO2017160861). BDH, KMW and SSH are part of Eicosis L.L.C., a company developing sEH inhibitors for clinical trials. (Project 5) 

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Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Archives of biochemistry and biophysics. 2017;613:1-11. Epub 2016/12/17. doi: 10.1016/j.abb.2016.10.017. PubMed PMID: 27983948; PMCID: PMC5172606. (Project 5) 

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Lee KSS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner K, Hammock BD. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorganic & medicinal chemistry. 2020;28(22):115735. Epub 2020/10/03. doi: 10.1016/j.bmc.2020.115735. PubMed PMID: 33007552. (Project 5 & Core B) 

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Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways. ACS central science. 2019;5(9):1614-24. Epub 2019/10/02. doi: 10.1021/acscentsci.9b00770. PubMed PMID: 31572788; PMCID: PMC6764161 California holds patents on the sEH inhibitors to treat disease. Some of these patents have been licensed by EicOsis L.L.C., a startup company advancing sEH inhibitors as potential therapeutics. BDH is cofounder and JY and KW are employees of EicOsis L.L.C. (Project 5 & Core B) 

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Li Z, Wang Y, Vasylieva N, Wan D, Yin Z, Dong J, Hammock BD. An Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Heptamer Fusion for the Detection of Tetrabromobisphenol A in Sediment. Analytical chemistry. 2020;92(14):10083-90. Epub 2020/06/20. doi: 10.1021/acs.analchem.0c01908. PubMed PMID: 32559059. (Project 3) 

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Li Z, Dong JX, Vasylieva N, Cui YL, Wan DB, Hua XD, Huo JQ, Yang DC, Gee SJ, Hammock BD. Highly specific nanobody against herbicide 2,4-dichlorophenoxyacetic acid for monitoring of its contamination in environmental water. The Science of the total environment. 2021;753:141950. Epub 2020/09/10. doi: 10.1016/j.scitotenv.2020.141950. PubMed PMID: 32906044; PMCID: Pmc7674261. (Project 3) 

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Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee KSS, Yang J, Zeng C, Hammock BD, Tong X. Inactivation of Cys(674) in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase. British journal of pharmacology. 2020;177(8):1793-805. Epub 2019/11/24. doi: 10.1111/bph.14937. PubMed PMID: 31758704; PMCID: PMC7070168 cardiovascular health. (Project 5) 

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Luo L, Wei XQ, Jia BZ, Yang JY, Shen YD, Hammock BD, Dong JX, Wang H, Lei HT, Xu ZL. Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. Biomolecules. 2019;9(10). Epub 2019/10/17. doi: 10.3390/biom9100597. PubMed PMID: 31614550; PMCID: PMC6843301. (Project 3) 

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Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(14):7083-8. Epub 2019/03/21. doi: 10.1073/pnas.1819234116. PubMed PMID: 30890645; PMCID: PMC6452650. (Project 5) 

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Martinez JA, Yang J, Wertheim BC, Roe DJ, Schriewer A, Lance P, Alberts DS, Hammock BD, Thompson PA. Celecoxib use and circulating oxylipins in a colon polyp prevention trial. PloS one. 2018;13(4):e0196398. Epub 2018/04/27. doi: 10.1371/journal.pone.0196398. PubMed PMID: 29698447; PMCID: PMC5919576. 

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Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM. Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation (New York, NY : 1994). 2020:e12653. Epub 2020/08/09. doi: 10.1111/micc.12653. PubMed PMID: 32767848. (Project 5) 

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McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in pharmacology. 2019;10:533. Epub 2019/06/20. doi: 10.3389/fphar.2019.00533. PubMed PMID: 31214021; PMCID: PMC6554663. (Project 5 & Core B) 

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O'Sullivan A, Henrick B, Dixon B, Barile D, Zivkovic A, Smilowitz J, Lemay D, Martin W, German JB, Schaefer SE. 21st century toolkit for optimizing population health through precision nutrition. Critical reviews in food science and nutrition. 2018;58(17):3004-15. Epub 2017/07/06. doi: 10.1080/10408398.2017.1348335. PubMed PMID: 28678528; PMCID: PMC6309929. 

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Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. Lipids. 2020;55(1):7-22. Epub 2019/11/07. doi: 10.1002/lipd.12197. PubMed PMID: 31691988; PMCID: PMC7220815. (Project 5) 

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Overby H, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, Zhao L. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. International journal of molecular sciences. 2020;21(19). Epub 2020/09/30. doi: 10.3390/ijms21197039. PubMed PMID: 32987880; PMCID: PMC7582898. (Project 5) 

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Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. The Journal of clinical investigation. 2019;129(7):2964-79. Epub 2019/06/18. doi: 10.1172/jci127282. PubMed PMID: 31205032; PMCID: PMC6597207. (Project 5) 

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Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wang D, Hwang SH, Hammock BD, Hashimoto K. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(21):11753-9. Epub 2020/05/14. doi: 10.1073/pnas.1922287117. PubMed PMID: 32398374; PMCID: PMC7260984. (Project 5) 

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Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(17):4370-5. Epub 2017/04/12. doi: 10.1073/pnas.1616893114. PubMed PMID: 28396419; PMCID: PMC5410821. (Project 5) 

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Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(13):E1944-52. Epub 2016/03/16. doi: 10.1073/pnas.1601532113. PubMed PMID: 26976569; PMCID: PMC4822604. (Project 5) 

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Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(25):E5815-e23. Epub 2018/05/08. doi: 10.1073/pnas.1802179115. PubMed PMID: 29735655; PMCID: PMC6016799. (Project 5) 

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Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD. One-Step Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Fusion for Detection of Aflatoxin B(1) in Cereal2019;67(18):5221-9. doi: 10.1021/acs.jafc.9b00688. PubMed PMID: 30883117. (Project 3) 

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Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY. Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils. Journal of agricultural and food chemistry. 2017;65(9):1941-51. Epub 2017/02/06. doi: 10.1021/acs.jafc.6b05559. PubMed PMID: 28157307; PMCID: PMC5581005. 

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Sanidad KZ, Yang H, Wang W, Ozay EI, Yang J, Gu M, Karner E, Zhang J, Kim D, Minter LM, Xiao H, Zhang G. Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice. Toxicological sciences : an official journal of the Society of Toxicology. 2018;163(2):490-9. Epub 2018/03/08. doi: 10.1093/toxsci/kfy045. PubMed PMID: 29514330. 

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Sethi S, Chen X, Kass PH, Puschner B. Polychlorinated biphenyl and polybrominated diphenyl ether profiles in serum from cattle, sheep, and goats across California. Chemosphere. 2017;181:63-73. Epub 2017/04/21. doi: 10.1016/j.chemosphere.2017.04.059. PubMed PMID: 28426942; PMCID: PMC5494844. 

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Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain, behavior, and immunity. 2019;81:535-44. Epub 2019/07/16. doi: 10.1016/j.bbi.2019.07.014. PubMed PMID: 31306773; PMCID: PMC6873816. (Project 5) 

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Shih PB. Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. Prostaglandins & other lipid mediators. 2017;132:69-76. Epub 2017/02/25. doi: 10.1016/j.prostaglandins.2017.02.002. PubMed PMID: 28232135; PMCID: PMC5565718. 

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Shih PB, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Molecular psychiatry. 2016;21(4):537-46. Epub 2015/04/01. doi: 10.1038/mp.2015.26. PubMed PMID: 25824304; PMCID: PMC4591075. (Project 5) 

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Sirish P, Thai PN, Lee JH, Yang J, Zhang XD, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem cells translational medicine. 2020. Epub 2020/08/14. doi: 10.1002/sctm.20-0143. PubMed PMID: 32790136. (Projects 4 & 5) 

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Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins, leukotrienes, and essential fatty acids. 2018;138:71-80. Epub 2016/06/11. doi: 10.1016/j.plefa.2016.05.004. PubMed PMID: 27282298; PMCID: PMC5106341. (Project 5) 

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Tao W, Tian J, Xu T, Xu L, Xie HQ, Zhou Z, Guo Z, Fu H, Yin X, Chen Y, Xu H, Zhang S, Zhang W, Ma C, Ji F, Yang J, Zhao B. Metabolic profiling study on potential toxicity in male mice treated with Dechlorane 602 using UHPLC-ESI-IT-TOF-MS. Environmental pollution (Barking, Essex : 1987). 2019;246:141-7. Epub 2018/12/12. doi: 10.1016/j.envpol.2018.11.086. PubMed PMID: 30537652. 

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Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. Journal of clinical toxicology. 2016;6(3). Epub 2017/03/04. doi: 10.4172/2161-0495.1000300. PubMed PMID: 28255523; PMCID: PMC5328659. 

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Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environment international. 2017;103:91-8. Epub 2017/03/28. doi: 10.1016/j.envint.2017.03.012. PubMed PMID: 28343720; PMCID: PMC5432128. (Project 3) 

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Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural brain research. 2017;326:69-76. Epub 2017/03/06. doi: 10.1016/j.bbr.2017.02.048. PubMed PMID: 28259677; PMCID: PMC5409858. (Project 4 & 5) 

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Wagner K, Lee KS, Yang J, Hammock BD. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. European journal of pain (London, England). 2017;21(3):456-65. Epub 2016/09/17. doi: 10.1002/ejp.939. PubMed PMID: 27634339; PMCID: PMC5300894. 

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Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine. Journal of lipid research. 2017;58(4):798-808. Epub 2017/02/06. doi: 10.1194/jlr.D073536. PubMed PMID: 28148721; PMCID: PMC5392736.  

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Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD. In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Frontiers in pharmacology. 2019;10:464. Epub 2019/05/31. doi: 10.3389/fphar.2019.00464. PubMed PMID: 31143115; PMCID: Pmc6520522. (Project 5) 

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Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin. Molecular cancer therapeutics. 2018;17(2):474-83. Epub 2017/12/30. doi: 10.1158/1535-7163.mct-16-0818. PubMed PMID: 29284644; PMCID: PMC5824635. (Project 5) 

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Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays. Analytical chemistry. 2019;91(2):1532-40. Epub 2018/12/07. doi: 10.1021/acs.analchem.8b04653. PubMed PMID: 30521755; PMCID: PMC7144541. (Project 3) 

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Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis2019;79(8):1822-30. doi: 10.1158/0008-5472.can-18-3221. PubMed PMID: 30803995. (Project 5) 

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Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring, Md). 2017;25(1):132-40. Epub 2016/11/29. doi: 10.1002/oby.21692. PubMed PMID: 27891824; PMCID: PMC5182168. (Project 5) 

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Wang W, Yang J, Yang H, Sanidad KZ, Hammock BD, Kim D, Zhang G. Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. Prostaglandins & other lipid mediators. 2016;127:9-13. Epub 2016/12/04. doi: 10.1016/j.prostaglandins.2016.11.003. PubMed PMID: 27913146; PMCID: PMC5628263.  

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Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(20):5283-8. Epub 2018/05/03. doi: 10.1073/pnas.1721711115. PubMed PMID: 29717038; PMCID: PMC5960306. (Project 5) 

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Wang Y, Li Z, Barnych B, Huo J, Wan D, Vasylieva N, Xu J, Li P, Liu B, Zhang C, Hammock BD. Investigation of the Small Size of Nanobodies for a Sensitive Fluorescence Polarization Immunoassay for Small Molecules: 3-Phenoxybenzoic Acid, an Exposure Biomarker of Pyrethroid Insecticides as a Model. Journal of agricultural and food chemistry. 2019;67(41):11536-41. Epub 2019/10/08. doi: 10.1021/acs.jafc.9b04621. PubMed PMID: 31589045; PMCID: PMC7134064. (Project 3)

 

Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler HJ. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2016;152(2):309-22. Epub 2016/05/22. doi: 10.1093/toxsci/kfw084. PubMed PMID: 27208083; PMCID: PMC4960907. (Project 5) 

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Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hwang SH, Jones RD, Hammock BD, Yang GY. Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer research. 2019;39(7):3651-60. Epub 2019/07/03. doi: 10.21873/anticanres.13513. PubMed PMID: 31262891; PMCID: Pmc7117872. 

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Xu J, Morisseau C, Yang J, Lee KSS, Kamita SG, Hammock BD. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect biochemistry and molecular biology. 2016;76:62-9. Epub 2016/07/03. doi: 10.1016/j.ibmb.2016.06.011. PubMed PMID: 27369469; PMCID: PMC5010450. (Project 5) 

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Yang H, Wang W, Romano KA, Gu M, Sanidad KZ, Kim D, Yang J, Schmidt B, Panigrahy D, Pei R, Martin DA, Ozay EI, Wang Y, Song M, Bolling BW, Xiao H, Minter LM, Yang G, Liu Z, Rey FE, Zhang G. A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice2018;10(443). doi: 10.1126/scitranslmed.aan4116. PubMed PMID: 29848663.

 

Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicology and applied pharmacology. 2019;382:114749. Epub 2019/09/16. doi: 10.1016/j.taap.2019.114749. PubMed PMID: 31521729; PMCID: PMC6957308. (Project 5) 

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Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. The Journal of nutritional biochemistry. 2017;49:8-14. Epub 2017/09/02. doi: 10.1016/j.jnutbio.2017.07.006. PubMed PMID: 28863368; PMCID: PMC5858941. 

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Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. Journal of neurochemistry. 2017;140(5):814-25. Epub 2016/12/22. doi: 10.1111/jnc.13933. PubMed PMID: 28002622; PMCID: PMC5310989. (Project 5 & Core B) 

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Zhao Y, Wan D, Yang J, Hammock BD, Ortiz de Montellano PR. Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates. Drug metabolism and disposition: the biological fate of chemicals. 2016;44(5):771-80. Epub 2016/03/05. doi: 10.1124/dmd.116.069633. PubMed PMID: 26936974; PMCID: PMC4851306. 

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