Project 5 Publications 

Papers from the current funding period

Ahn KC, Ranganathan A, Bever CS, Hwang SH, Holland EB, Morisseau C, Pessah IN, Hammock BD, Gee SJ. Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay. Environmental science & technology. 2016;50(7):3754-61. Epub 2016/03/05. doi: 10.1021/acs.est.5b05357. PubMed PMID: 26937944; PMCID: PMC4821808. (Project 3, Core B) 

Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock B, Mozaffarian D. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. Journal of lipid research. 2016;57(3):492-8. Epub 2016/01/11. doi: 10.1194/jlr.P062398. PubMed PMID: 26749073; PMCID: PMC4766998. (Core A) 

Atone J, Wagner K, Hashimoto K, Hammock BD. Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases. Prostaglandins & other lipid mediators. 2020;147:106385. Epub 2019/11/08. doi: 10.1016/j.prostaglandins.2019.106385. PubMed PMID: 31698143; PMCID: PMC7067627. 

Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry. 2016;55(5):788-97. Epub 2016/01/12. doi: 10.1021/acs.biochem.5b01229. PubMed PMID: 26752215; PMCID: PMC4765904(Dartmouth College SRC) 

Bailey KA, Moreno E, Haj FG, Simon SI, Passerini AG. Mechanoregulation of p38 activity enhances endoplasmic reticulum stress-mediated inflammation by arterial endothelium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019;33(11):12888-99. Epub 2019/09/10. doi: 10.1096/fj.201900236R. PubMed PMID: 31499005; PMCID: PMC6902662. 

Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. PloS one. 2015;10(12):e0144996. Epub 2015/12/18. doi: 10.1371/journal.pone.0144996. PubMed PMID: 26672987; PMCID: PMC4681469. (Core A) 

Bettaieb A, Koike S, Chahed S, Zhao Y, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG. Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. The FEBS journal. 2017;284(13):1970-86. Epub 2017/05/10. doi: 10.1111/febs.14100. PubMed PMID: 28485854; PMCID: PMC5515292. 

Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochimica et biophysica acta General subjects. 2017;1861(11 Pt A):2758-65. Epub 2017/08/02. doi: 10.1016/j.bbagen.2017.07.021. PubMed PMID: 28757338; PMCID: PMC5873293. 

Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. Journal of medicinal chemistry. 2018;61(8):3541-50. Epub 2018/04/04. doi: 10.1021/acs.jmedchem.7b01804. PubMed PMID: 29614224; PMCID: PMC5933862. (Core B) 

Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry letters. 2015;25(23):5514-9. Epub 2015/11/02. doi: 10.1016/j.bmcl.2015.10.066. PubMed PMID: 26520661; PMCID: PMC4654407. (Core B) 

Burmistrov V, Morisseau C, D'Yachenko V, Karlov D, Butov GM, Hammock BD. Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorganic & medicinal chemistry letters. 2020;30(3):126908. Epub 2019/12/25. doi: 10.1016/j.bmcl.2019.126908. PubMed PMID: 31870649; PMCID: PMC6957307. (Core B) 

Burmistrov V, Morisseau C, D'Yachenko V, Rybakov VB, Butov GM, Hammock BD. Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. Journal of fluorine chemistry. 2019;220:48-53. Epub 2020/03/07. doi: 10.1016/j.jfluchem.2019.02.005. PubMed PMID: 32132741; PMCID: PMC7055688. (Core B) 

Burmistrov V, Morisseau C, Harris TR, Butov G, Hammock BD. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorganic chemistry. 2018;76:510-27. Epub 2018/01/09. doi: 10.1016/j.bioorg.2017.12.024. PubMed PMID: 29310082; PMCID: PMC5837815. (Core B) 

Burmistrov V, Morisseau C, Karlov D, Pitushkin D, Vernigora A, Rasskazova E, Butov GM, Hammock BD. Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry letters. 2020;30(18):127430. Epub 2020/08/01. doi: 10.1016/j.bmcl.2020.127430. PubMed PMID: 32736212; PMCID: Pmc7494652. (Core B) 

Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry letters. 2018;28(13):2302-13. Epub 2018/05/29. doi: 10.1016/j.bmcl.2018.05.024. PubMed PMID: 29803731; PMCID: PMC6442743. (Core B) 

Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Erakovic Haber V, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. Journal of Alzheimer's disease : JAD. 2018;62(4):1663-81. Epub 2018/03/06. doi: 10.3233/jad-170875. PubMed PMID: 29504531; PMCID: PMC7065497. (Project 3) 

Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS. Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. Toxicology letters. 2016;246:35-41. Epub 2016/02/04. doi: 10.1016/j.toxlet.2016.01.019. PubMed PMID: 26840748; PMCID: PMC4774530. 

Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L. Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. Kidney & blood pressure research. 2018;43(2):329-49. Epub 2018/03/13. doi: 10.1159/000487902. PubMed PMID: 29529602; PMCID: PMC5985203. 

Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. Journal of hypertension. 2018;36(6):1326-41. Epub 2018/03/24. doi: 10.1097/hjh.0000000000001708. PubMed PMID: 29570510; PMCID: PMC7375140. 

Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, Pérez B, Pérez C, Rodríguez-Franco MI, Leiva R, Osuna S, Morisseau C, Hammock BD, Vázquez-Carrera M, Vázquez S. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. Journal of medicinal chemistry. 2020;63(17):9237-57. doi: 10.1021/acs.jmedchem.0c00310. PubMed PMID: 32787085. (Core B) 

Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, Morisseau C, Hammock BD, Vázquez S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorganic & medicinal chemistry. 2019;27(20):115078. Epub 2019/09/07. doi: 10.1016/j.bmc.2019.115078. PubMed PMID: 31488357; PMCID: PMC6892585. (Core B) 

de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International journal of biological macromolecules. 2019;129:653-8. Epub 2019/02/17. doi: 10.1016/j.ijbiomac.2019.02.070. PubMed PMID: 30771398; PMCID: PMC6447457. (Core B) 

de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular biology reports. 2019;46(1):371-9. Epub 2018/11/15. doi: 10.1007/s11033-018-4481-4. PubMed PMID: 30426381; PMCID: PMC6426676. (Core B) 

Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver. Frontiers in pharmacology. 2019;10:580. Epub 2019/06/14. doi: 10.3389/fphar.2019.00580. PubMed PMID: 31191316; PMCID: Pmc6548860. (Core A) 

Duflot T, Moreau-Grangé L, Roche C, Iacob M, Wils J, Rémy-Jouet I, Cailleux AF, Leuillier M, Renet S, Li D, Morisseau C, Lamoureux F, Richard V, Prévost G, Joannidès R, Bellien J. Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. Cardiovascular diabetology. 2019;18(1):35. Epub 2019/03/20. doi: 10.1186/s12933-019-0843-z. PubMed PMID: 30885203; PMCID: PMC6423843. (Project 3 & Core B) 

Fishbein A, Hammock BD, Serhan CN, Panigrahy D. Carcinogenesis: Failure of resolution of inflammation? Pharmacology & therapeutics. 2020;218:107670. Epub 2020/09/07. doi: 10.1016/j.pharmthera.2020.107670. PubMed PMID: 32891711; PMCID: Pmc7470770. 

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C,  Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(1):136-41. Epub 2016/12/17. doi: 10.1073/pnas.1610242114. PubMed PMID: 27980032; PMCID: Pmc5224368. (Core A, Dartmouth College SRC) 

Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(5):1698-703. Epub 2019/01/17. doi: 10.1073/pnas.1803999116. PubMed PMID: 30647111; PMCID: PMC6358686. (Core A) 

Ghosh R, Goswami SK, Feitoza L, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. International journal of cardiology. 2016;223:923-35. Epub 2016/09/03. doi: 10.1016/j.ijcard.2016.08.233. PubMed PMID: 27589040; PMCID: PMC5076377. (Project 4) 

Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arteriosclerosis, thrombosis, and vascular biology. 2016;36(9):1919-27. Epub 2016/07/16. doi: 10.1161/atvbaha.116.307558. PubMed PMID: 27417579; PMCID: PMC5010176. 

Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicology and applied pharmacology. 2015;289(3):419-27. Epub 2015/11/03. doi: 10.1016/j.taap.2015.10.018. PubMed PMID: 26522832; PMCID: PMC4666679. (Core A) 

Goswami SK, Rand AA, Wan D, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang GY, Hammock BD. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life sciences. 2017;180:114-22. Epub 2017/05/20. doi: 10.1016/j.lfs.2017.05.018. PubMed PMID: 28522175; PMCID: PMC5659729. (Core A) 

Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD. Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers. The Journal of pharmacology and experimental therapeutics. 2016;357(3):529-36. Epub 2016/03/19. doi: 10.1124/jpet.116.232108. PubMed PMID: 26989141; PMCID: PMC4885505. (Core A) 

Goswami SK, Yang GY, Gomes A, Hammock BD. Novel approaches to manage toxicity of diclofenac in the gastrointestinal tract. In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects. Athens, Greece: Nova Medicine and Health; 2019. p. 125-61. (Project 4) 

Goswami SK, Yang GY, Tiwari S, Hammock BD, Gomes A. Mitochondrial and Proteasomal Dysfunction as a Possbile Mechanism of Cardiovascular Toxicity of Diclofenac. In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects. Athens, Greece: Nova Medicine and Health; 2019. p. 163-75. (Project 4) 

Guedes A, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine veterinary journal. 2017;49(3):345-51. Epub 2016/06/25. doi: 10.1111/evj.12603. PubMed PMID: 27338788; PMCID: PMC5580818. 

Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. Journal of veterinary pharmacology and therapeutics. 2018;41(2):230-8. Epub 2017/10/27. doi: 10.1111/jvp.12463. PubMed PMID: 29067696; PMCID: PMC5920688. (Core A) 

Hammock BD, Wang W, Gilligan MM, Panigrahy D. Eicosanoids: The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)? The American journal of pathology. 2020;190(9):1782-8. Epub 2020/07/11. doi: 10.1016/j.ajpath.2020.06.010. PubMed PMID: 32650004; PMCID: PMC7340586. 

Hao L, Kearns J, Scott S, Wu D, Kodani SD, Morisseau C, Hammock BD, Sun X, Zhao L, Wang S. Indomethacin Enhances Brown Fat Activity. The Journal of pharmacology and experimental therapeutics. 2018;365(3):467-75. Epub 2018/03/24. doi: 10.1124/jpet.117.246256. PubMed PMID: 29567865; PMCID: PMC5931432. 

Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. Molecular pharmacology. 2018;94(2):834-41. Epub 2018/05/31. doi: 10.1124/mol.118.111831. PubMed PMID: 29844231; PMCID: PMC6022802. (Core A) 

Harris TR, Kodani S, Yang J, Imai DM, Hammock BD. An ω-3-enriched diet alone does not attenuate CCl(4)-induced hepatic fibrosis. The Journal of nutritional biochemistry. 2016;38:93-101. Epub 2016/10/13. doi: 10.1016/j.jnutbio.2016.08.010. PubMed PMID: 27732914; PMCID: PMC5102762. (Core A) 

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(36):E7545-e53. Epub 2017/08/23. doi: 10.1073/pnas.1620898114. PubMed PMID: 28827330; PMCID: PMC5594641. 

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E. Computer-Aided Selective Optimization of Side Activities of Talinolol. ACS medicinal chemistry letters. 2019;10(6):899-903. Epub 2019/06/22. doi: 10.1021/acsmedchemlett.9b00075. PubMed PMID: 31223445; PMCID: Pmc6580380. (Core B) 

Hildreth K, Kodani SD, Hammock BD, Zhao L. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies. The Journal of nutritional biochemistry. 2020;86:108484. Epub 2020/08/23. doi: 10.1016/j.jnutbio.2020.108484. PubMed PMID: 32827665; PMCID: PMC7606796. 

Hrdlička J, Neckář J, Papoušek F, Husková Z, Kikerlová S, Vaňourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Červenka L, Kolář F. Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats. Frontiers in pharmacology. 2019;10:159. Epub 2019/03/19. doi: 10.3389/fphar.2019.00159. PubMed PMID: 30881303; PMCID: PMC6406051. 

Hsu MF, Koike S, Mello A, Nagy LE, Haj FG. Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice. Redox biology. 2020;36:101658. Epub 2020/08/10. doi: 10.1016/j.redox.2020.101658. PubMed PMID: 32769011; PMCID: PMC7408361. 

 Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure (London, England : 1993). 2017;25(5):697-707.e4. Epub 2017/04/11. doi: 10.1016/j.str.2017.03.002. PubMed PMID: 28392259; PMCID: PMC5524515. (Dartmouth College SRC) 

Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorganic & medicinal chemistry letters. 2017;27(3):620-5. Epub 2016/12/28. doi: 10.1016/j.bmcl.2016.12.002. PubMed PMID: 28025003; PMCID: PMC5584617. (Core A) 

Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins & other lipid mediators. 2017;133:68-78. Epub 2017/08/30. doi: 10.1016/j.prostaglandins.2017.08.003. PubMed PMID: 28847566; PMCID: PMC5824649. (Project 4) 

Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Lee KS, Hwang SH, Hammock BD. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovascular therapeutics. 2017;35(3). Epub 2017/03/16. doi: 10.1111/1755-5922.12259. PubMed PMID: 28296232; PMCID: PMC5597338. 

Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain, behavior, and immunity. 2019;81:545-

59. Epub 2019/07/22. doi: 10.1016/j.bbi.2019.07.015. PubMed PMID: 31325531; PMCID: PMC7155744. (Project 3 & Core B) 

Kandhi S, Zhang B, Froogh G, Qin J, Alruwaili N, Le Y, Yang YM, Hwang SH, Hammock BD, Wolin MS, Huang A, Sun D. EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. American journal of physiology Lung cellular and molecular physiology. 2017;313(2):L350-l9. Epub 2017/04/30. doi: 10.1152/ajplung.00038.2017. PubMed PMID: 28450284; PMCID: PMC5582931. 

Kim J, Ulu A, Wan D, Yang J, Hammock BD, Weiss RH. Addition of DHA Synergistically Enhances the Efficacy of Regorafenib for Kidney Cancer Therapy. Molecular cancer therapeutics. 2016;15(5):890-8. Epub 2016/02/28. doi: 10.1158/1535-7163.mct-15-0847. PubMed PMID: 26921392; PMCID: PMC4873345. (Core A) 

Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck WH, Hammock BD, Riemekasten G, Enghard P. Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice. Scientific reports. 2019;9(1):8993. Epub 2019/06/22. doi: 10.1038/s41598-019-45299-5. PubMed PMID: 31222024; PMCID: PMC6586931 

 

Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & medicinal chemistry letters. 2018;28(4):762-8. Epub 2018/01/26. doi: 10.1016/j.bmcl.2018.01.003. PubMed PMID: 29366648; PMCID: PMC5837813. (Core B) 

Kodani SD, Morisseau C. Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. Biochimie. 2019;159:59-65. Epub 2019/02/05. doi: 10.1016/j.biochi.2019.01.020. PubMed PMID: 30716359; PMCID: PMC6431267. 

Kodani SD, Overby HB, Morisseau C, Chen J, Zhao L, Hammock BD. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicology letters. 2016;262:92-9. Epub 2016/10/25. doi: 10.1016/j.toxlet.2016.09.011. PubMed PMID: 27659731; PMCID: PMC5096949. 

Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS omega. 2018;3(10):14076-86. Epub 2018/11/10. doi: 10.1021/acsomega.8b01625. PubMed PMID: 30411058; PMCID: PMC6210075 authors on a patent own by the University of California for compounds presented in this text (WO2017160861). BDH, KMW and SSH are part of Eicosis L.L.C., a company developing sEH inhibitors for clinical trials. (Core A) 

Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. Journal of medicinal chemistry. 2019;62(18):8443-60. Epub 2019/08/23. doi: 10.1021/acs.jmedchem.9b00445. PubMed PMID: 31436984; PMCID: PMC7262789. (Core B)

 

Lakkappa N, Krishnamurthy PT, Yamjala K, Hwang SH, Hammock BD, Babu B. Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. Journal of pharmaceutical and biomedical analysis. 2018;149:457-64. Epub 2017/11/24. doi: 10.1016/j.jpba.2017.11.043. PubMed PMID: 29169114; PMCID: PMC5843369. 

Lassabe G, Kramer K, Hammock BD, González-Sapienza G, González-Techera A. Noncompetitive Homogeneous Detection of Small Molecules Using Synthetic Nanopeptamer-Based Luminescent Oxygen Channeling. Analytical chemistry. 2018;90(10):6187-92. Epub 2018/04/26. doi: 10.1021/acs.analchem.8b00657. PubMed PMID: 29694028; PMCID: PMC5963685.

 

Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Archives of biochemistry and biophysics. 2017;613:1-11. Epub 2016/12/17. doi: 10.1016/j.abb.2016.10.017. PubMed PMID: 27983948; PMCID: PMC5172606. (Core A) 

Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways. ACS central science. 2019;5(9):1614-24. Epub 2019/10/02. doi: 10.1021/acscentsci.9b00770. PubMed PMID: 31572788; PMCID: PMC6764161 California holds patents on the sEH inhibitors to treat disease. Some of these patents have been licensed by EicOsis L.L.C., a startup company advancing sEH inhibitors as potential therapeutics. BDH is cofounder and JY and KW are employees of EicOsis L.L.C. (Core A & B) 

Li D, Cui Y, Morisseau C, Gee SJ, Bever CS, Liu X, Wu J, Hammock BD, Ying Y. Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP? Analytical chemistry. 2017;89(11):6248-56. Epub 2017/05/04. doi: 10.1021/acs.analchem.7b01247. PubMed PMID: 28460522; PMCID: PMC5611449. (Project 3 & Core B) 

Li D, Cui Y, Morisseau C, Wagner KM, Cho YS, Hammock BD. Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer. Analytical chemistry. 2020;92(17):11654-63. Epub 2020/08/14. doi: 10.1021/acs.analchem.0c01511. PubMed PMID: 32786492. (Project 3 and Core B) 

Li D, Liu Y, Zhang X, Lv H, Pang W, Sun X, Gan LM, Hammock BD, Ai D, Zhu Y. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice. Journal of molecular and cellular cardiology. 2016;98:128-37. Epub 2016/08/09. doi: 10.1016/j.yjmcc.2016.08.001. PubMed PMID: 27496380; PMCID: PMC5559083. (Core B) 

Li D, Morisseau C, McReynolds CB, Duflot T, Bellien J, Nagra RM, Taha AY, Hammock BD. Development of Improved Double-Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detection in Peripheral Blood Mononuclear Cells of Diabetic Patients and the Prefrontal Cortex of Multiple Sclerosis Patients. Analytical chemistry. 2020;92(10):7334-42. doi: 10.1021/acs.analchem.0c01115. PubMed PMID: 32253910. (Project 2 & 3 and Core B) 

Li Q, Kailemia MJ, Merleev AA, Xu G, Serie D, Danan LM, Haj FG, Maverakis E, Lebrilla CB. Site-Specific Glycosylation Quantitation of 50 Serum Glycoproteins Enhanced by Predictive Glycopeptidomics for Improved Disease Biomarker Discovery. Analytical chemistry. 2019;91(8):5433-45. Epub 2019/03/19. doi: 10.1021/acs.analchem.9b00776. PubMed PMID: 30882205. 

Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells. ACS chemical neuroscience. 2019;10(9):4018-30. Epub 2019/08/06. doi: 10.1021/acschemneuro.9b00271. PubMed PMID: 31378059; PMCID: PMC7028313. 

Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee KSS, Yang J, Zeng C, Hammock BD, Tong X. Inactivation of Cys(674) in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase. British journal of pharmacology. 2020;177(8):1793-805. Epub 2019/11/24. doi: 10.1111/bph.14937. PubMed PMID: 31758704; PMCID: PMC7070168 cardiovascular health. (Core A) 

Liu JY, Morisseau C, Huang H, Hammock BD. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. Journal of ethnopharmacology. 2016;194:475-82. Epub 2016/10/06. doi: 10.1016/j.jep.2016.09.044. PubMed PMID: 27702689; PMCID: PMC5584568. (Core B) 

Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochemical pharmacology. 2015;98(4):718-31. Epub 2015/10/24. doi: 10.1016/j.bcp.2015.10.013. PubMed PMID: 26494425; PMCID: PMC4656071. (Core A & B) 

Liu YX, Karsai A, Anderson DS, Silva RM, Uyeminami DL, Van Winkle LS, Pinkerton KE, Liu GY. Single-Cell Mechanics Provides an Effective Means To Probe in Vivo Interactions between Alveolar Macrophages and Silver Nanoparticles. The journal of physical chemistry B. 2015;119(49):15118-29. Epub 2015/11/13. doi: 10.1021/acs.jpcb.5b07656. PubMed PMID: 26562364. 

Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY. Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(11):5154-9. Epub 2019/02/26. doi: 10.1073/pnas.1815746116. PubMed PMID: 30804206; PMCID: PMC6421466. 

Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(14):7083-8. Epub 2019/03/21. doi: 10.1073/pnas.1819234116. PubMed PMID: 30890645; PMCID: PMC6452650. 

McReynolds C, Morisseau C, Wagner K, Hammock B. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. Advances in experimental medicine and biology. 2020;1274:71-99. Epub 2020/09/08. doi: 10.1007/978-3-030-50621-6_5. PubMed PMID: 32894508; PMCID: Pmc7737916. 

McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in pharmacology. 2019;10:533. Epub 2019/06/20. doi: 10.3389/fphar.2019.00533. PubMed PMID: 31214021; PMCID: PMC6554663. (Core A & B) 

Mello A, Hsu MF, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease. Cellular and molecular gastroenterology and hepatology. 2020. Epub 2020/10/18. doi: 10.1016/j.jcmgh.2020.10.002. PubMed PMID: 33068774. (Core A) 

Minaz N, Razdan R, Hammock BD, Goswami SK. An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Prostaglandins & other lipid mediators. 2018;136:84-9. Epub 2018/05/12. doi: 10.1016/j.prostaglandins.2018.05.004. PubMed PMID: 29751149; PMCID: PMC6402559. 

Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK. Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019;115:108897. Epub 2019/05/19. doi: 10.1016/j.biopha.2019.108897. PubMed PMID: 31102913; PMCID: PMC6893866. 

Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A(2). Bioorganic & medicinal chemistry. 2016;24(20):4801-11. Epub 2016/06/21. doi: 10.1016/j.bmc.2016.05.009. PubMed PMID: 27320659; PMCID: PMC5053890. (Core B) 

Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. Journal of periodontal research. 2018;53(5):743-9. Epub 2018/06/01. doi: 10.1111/jre.12559. PubMed PMID: 29851077; PMCID: PMC6168335. 

Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. American journal of physiology Lung cellular and molecular physiology. 2017;313(2):L252-l66. Epub 2017/05/06. doi: 10.1152/ajplung.00453.2016. PubMed PMID: 28473326; PMCID: PMC5582936. (Core B) 

Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. Lipids. 2020;55(1):7-22. Epub 2019/11/07. doi: 10.1002/lipd.12197. PubMed PMID: 31691988; PMCID: PMC7220815. (Core A) 

Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. The Journal of clinical investigation. 2019;129(7):2964-79. Epub 2019/06/18. doi: 10.1172/jci127282. PubMed PMID: 31205032; PMCID: PMC6597207. (Core A) 

Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? Cancer metastasis reviews. 2020;39(2):337-40. Epub 2020/05/10. doi: 10.1007/s10555-020-09889-4. PubMed PMID: 32385712; PMCID: PMC7207990. 

Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes. Frontiers in pharmacology. 2019;10:288. Epub 2019/05/10. doi: 10.3389/fphar.2019.00288. PubMed PMID: 31068802; PMCID: Pmc6491817. 

Patchin ES, Anderson DS, Silva RM, Uyeminami DL, Scott GM, Guo T, Van Winkle LS, Pinkerton KE. Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain. Environmental health perspectives. 2016;124(12):1870-5. Epub 2016/05/07. doi: 10.1289/ehp234. PubMed PMID: 27152509; PMCID: PMC5132640. 

Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani S, Halim M, Morisseau C, Hammock BD, Deng SX. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins & other lipid mediators. 2018;136:90-5. Epub 2018/03/24. doi: 10.1016/j.prostaglandins.2018.02.004. PubMed PMID: 29567338; PMCID: PMC5970965. (Core B) 

Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(17):4370-5. Epub 2017/04/12. doi: 10.1073/pnas.1616893114. PubMed PMID: 28396419; PMCID: PMC5410821. (Core A) 

Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C. LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide. Methods in molecular biology (Clifton, NJ). 2018;1730:123-33. Epub 2018/01/25. doi: 10.1007/978-1-4939-7592-1_10. PubMed PMID: 29363071; PMCID: PMC5831730. (Core A) 

Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. Journal of lipid research. 2019;60(12):1996-2005. Epub 2019/10/24. doi: 10.1194/jlr.M094219. PubMed PMID: 31641036; PMCID: PMC6889709. (Core A) 

Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(13):E1944-52. Epub 2016/03/16. doi: 10.1073/pnas.1601532113. PubMed PMID: 26976569; PMCID: PMC4822604. (Core A) 

Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(25):E5815-e23. Epub 2018/05/08. doi: 10.1073/pnas.1802179115. PubMed PMID: 29735655; PMCID: PMC6016799. (Core A) 

Rossotti MA, Pirez M, Gonzalez-Techera A, Cui Y, Bever CS, Lee KS, Morisseau C, Leizagoyen C, Gee S, Hammock BD, González-Sapienza G. Method for Sorting and Pairwise Selection of Nanobodies for the Development of Highly Sensitive Sandwich Immunoassays. Analytical chemistry. 2015;87(23):11907-14. Epub 2015/11/07. doi: 10.1021/acs.analchem.5b03561. PubMed PMID: 26544909; PMCID: PMC4666776. (Project 3) 

Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. International journal of molecular sciences. 2016;17(5). Epub 2016/05/24. doi: 10.3390/ijms17050751. PubMed PMID: 27213332; PMCID: PMC4881572. 

Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain, behavior, and immunity. 2019;81:535-44. Epub 2019/07/16. doi: 10.1016/j.bbi.2019.07.014. PubMed PMID: 31306773; PMCID: PMC6873816. (Core A) 

Shih PB, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Molecular psychiatry. 2016;21(4):537-46. Epub 2015/04/01. doi: 10.1038/mp.2015.26. PubMed PMID: 25824304; PMCID: PMC4591075. (Core A) 

Stefanovski D, Shih PB, Hammock BD, Watanabe RM, Youn JH. Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins & other lipid mediators. 2020;148:106410. Epub 2020/01/14. doi: 10.1016/j.prostaglandins.2020.106410. PubMed PMID: 31931080; PMCID: PMC7237305. 

Sun CP, Zhang J, Zhao WY, Yi J, Yan JK, Wang YL, Morisseau C, Liu ZB, Hammock BD, Ma XC. Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Bioorganic chemistry. 2020;96:103637. Epub 2020/02/08. doi: 10.1016/j.bioorg.2020.103637. PubMed PMID: 32032849; PMCID: PMC7233170. (Core B) 

Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KS, Inceoglu B, Wan D, Boyce ST, Hammock BD. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plastic and reconstructive surgery Global open. 2016;4(12):e1151. Epub 2017/03/16. doi: 10.1097/gox.0000000000001151. PubMed PMID: 28293507; PMCID: PMC5222652. 

Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins, leukotrienes, and essential fatty acids. 2018;138:71-80. Epub 2016/06/11. doi: 10.1016/j.plefa.2016.05.004. PubMed PMID: 27282298; PMCID: PMC5106341. (Project 2 & Core A) 

Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. Journal of molecular and cellular cardiology. 2016;92:30-40. Epub 2016/01/27. doi: 10.1016/j.yjmcc.2016.01.020. PubMed PMID: 26812119; PMCID: PMC5008453. (Core A) 

Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis. The Journal of pharmacology and experimental therapeutics. 2017;361(3):408-16. Epub 2017/03/31. doi: 10.1124/jpet.116.238113. PubMed PMID: 28356494; PMCID: PMC5443319. 

Trindade-da-Silva CA, Clemente-Napimoga JT, Abdalla HB, Rosa SM, Ueira-Vieira C, Morisseau C, Verri WA, Jr., Montalli VAM, Hammock BD, Napimoga MH. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020;34(7):9074-86. Epub 2020/05/14. doi: 10.1096/fj.202000415R. PubMed PMID: 32400048; PMCID: PMC7383812.

 

Tu M, Wang W, Hammock BD, Zhang G. ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved2020;12(11). doi: 10.3390/nu12113301. PubMed PMID: 33126566. 

Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Scientific reports. 2018;8(1):5279. Epub 2018/03/29. doi: 10.1038/s41598-018-23504-1. PubMed PMID: 29588470; PMCID: PMC5869703 inhibitors. R. Tu, J. Armstrong, K.S.S. Lee, A. Sapirstein, and R.C. Koehler declare that they have no conflict of interest. 

Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural brain research. 2017;326:69-76. Epub 2017/03/06. doi: 10.1016/j.bbr.2017.02.048. PubMed PMID: 28259677; PMCID: PMC5409858. (Core A) 

Wagner KM, Atone J, Hammock BD. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain research. 2020;1728:146573. Epub 2019/12/04. doi: 10.1016/j.brainres.2019.146573. PubMed PMID: 31790682; PMCID: PMC6996511. 

Wagner KM, Gomes A, McReynolds CB, Hammock BD. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2020;17(3):900-16. Epub 2020/09/03. doi: 10.1007/s13311-020-00916-4. PubMed PMID: 32875445; PMCID: PMC7609775. (Project 4)

 

Wagner KM, McReynolds CB, Schmidt WK, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacology & therapeutics. 2017;180:62-76. Epub 2017/06/24. doi: 10.1016/j.pharmthera.2017.06.006. PubMed PMID: 28642117; PMCID: PMC5677555. 

Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD. In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Frontiers in pharmacology. 2019;10:464. Epub 2019/05/31. doi: 10.3389/fphar.2019.00464. PubMed PMID: 31143115; PMCID: Pmc6520522. (Core A) 

Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin. Molecular cancer therapeutics. 2018;17(2):474-83. Epub 2017/12/30. doi: 10.1158/1535-7163.mct-16-0818. PubMed PMID: 29284644; PMCID: PMC5824635. (Core A) 

Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ. Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis2019;79(8):1822-30. doi: 10.1158/0008-5472.can-18-3221. PubMed PMID: 30803995. (Core A) 

Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring, Md). 2017;25(1):132-40. Epub 2016/11/29. doi: 10.1002/oby.21692. PubMed PMID: 27891824; PMCID: PMC5182168. (Core A) 

Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(20):5283-8. Epub 2018/05/03. doi: 10.1073/pnas.1721711115. PubMed PMID: 29717038; PMCID: PMC5960306. (Core A) 

Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hwang SH, Kim D, Lee KSS, Xiao H, Hammock BD, Zhang G. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(15):8431-6. Epub 2020/03/30. doi: 10.1073/pnas.1916189117. PubMed PMID: 32220957; PMCID: PMC7165420. (Core A) 

Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock BD, Rock DA, Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug metabolism and disposition: the biological fate of chemicals. 2017;45(7):712-20. Epub 2017/04/22. doi: 10.1124/dmd.117.075226. PubMed PMID: 28428366; PMCID: PMC5452678. (Core B)

Wu X, Yang J, Morisseau C, Robertson LW, Hammock B, Lehmler HJ. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2016;152(2):309-22. Epub 2016/05/22. doi: 10.1093/toxsci/kfw084. PubMed PMID: 27208083; PMCID: PMC4960907. (Core A and U of Iowa SRC) 

Xu J, Morisseau C, Yang J, Lee KSS, Kamita SG, Hammock BD. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect biochemistry and molecular biology. 2016;76:62-9. Epub 2016/07/03. doi: 10.1016/j.ibmb.2016.06.011. PubMed PMID: 27369469; PMCID: PMC5010450. (Core A) 

Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. Journal of lipid research. 2018;59(4):684-95. Epub 2018/02/21. doi: 10.1194/jlr.M082701. PubMed PMID: 29459481; PMCID: PMC5880498. 

Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicology and applied pharmacology. 2019;382:114749. Epub 2019/09/16. doi: 10.1016/j.taap.2019.114749. PubMed PMID: 31521729; PMCID: PMC6957308. (Core A) 

Yang J, Shih PB. Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder. Data in brief. 2018;17:334-8. Epub 2018/06/08. doi: 10.1016/j.dib.2018.01.028. PubMed PMID: 29876402; PMCID: Pmc5988286. (Core A) 

Yang YM, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(3):613-8. Epub 2018/01/04. doi: 10.1073/pnas.1716016115. PubMed PMID: 29295935; PMCID: PMC5776989.

 

Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Progress in neurobiology. 2019;172:23-39. Epub 2018/11/18. doi: 10.1016/j.pneurobio.2018.11.001. PubMed PMID: 30447256; PMCID: PMC6993804. 

Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence. The FEBS journal. 2020;287(8):1666-80. Epub 2019/10/28. doi: 10.1111/febs.15105. PubMed PMID: 31646730; PMCID: PMC7174142. 

Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis. Journal of affective disorders. 2020;270:131-4. Epub 2020/04/28. doi: 10.1016/j.jad.2020.03.070. PubMed PMID: 32339103; PMCID: PMC7243919. 

Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. Journal of neurochemistry. 2017;140(5):814-25. Epub 2016/12/22. doi: 10.1111/jnc.13933. PubMed PMID: 28002622; PMCID: PMC5310989. (Core B)