SUMMARY

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Bioremediation is often limited for superfund site remediation by slow transformation rates and/or buildup of transformation products, possibly having higher toxicity than the parent compounds. This project will demonstrate significant improvements in bioremediation via a multi-prong effort involving non-target chemical analysis, a comprehensive suite of bioassays and enzyme engineering. It will thus lead to reductions in human exposure to bioactive compounds and to more rapid and effective site cleanups, making it of direct interest to Superfund Research Program stakeholders, especially communities like the Yurok Tribe that face unknown contamination scenarios.