Project 4 Publications 

Papers from the current funding period

Carbonell T, Gomes AV. MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury. Redox biology. 2020;36:101607. Epub 2020/06/28. doi: 10.1016/j.redox.2020.101607. PubMed PMID: 32593128; PMCID: Pmc7322687. 

Frederich BJ, Timofeyev V, Thai PN, Haddad MJ, Poe AJ, Lau VC, Moshref M, Knowlton AA, Sirish P, Chiamvimonvat N. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart rhythm. 2017;14(11):1685-92. Epub 2017/07/03. doi: 10.1016/j.hrthm.2017.06.038. PubMed PMID: 28668623; PMCID: PMC5671891. 

Ghosh R, Goswami SK, Feitoza L, Hammock B, Gomes AV. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. International journal of cardiology. 2016;223:923-35. Epub 2016/09/03. doi: 10.1016/j.ijcard.2016.08.233. PubMed PMID: 27589040; PMCID: PMC5076377. (Project 5) 

Goswami SK, Yang GY, Gomes A, Hammock BD. Novel approaches to manage toxicity of diclofenac in the gastrointestinal tract. In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects. Athens, Greece: Nova Medicine and Health; 2019. p. 125-61. (Projects 3 & 5) 

Goswami SK, Yang GY, Tiwari S, Hammock BD, Gomes A. Mitochondrial and Proteasomal Dysfunction as a Possbile Mechanism of Cardiovascular Toxicity of Diclofenac. In: Yiannakopoulou E, editor. Diclofenac: Pharmacology, Uses and Adverse Effects. Athens, Greece: Nova Medicine and Health; 2019. p. 163-75. (Projects 3 & 5) 

Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins & other lipid mediators. 2017;133:68-78. Epub 2017/08/30. doi: 10.1016/j.prostaglandins.2017.08.003. PubMed PMID: 28847566; PMCID: PMC5824649. (Project 5) 

Mishra M, Tiwari S, Gomes AV. Protein purification and analysis: next generation Western blotting techniques. Expert review of proteomics. 2017;14(11):1037-53. Epub 2017/10/05. doi: 10.1080/14789450.2017.1388167. PubMed PMID: 28974114; PMCID: Pmc6810642. 

Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis. 2019;40(12-13):1731-9. Epub 2019/04/26. doi: 10.1002/elps.201900059. PubMed PMID: 31021001; PMCID: PMC7036291. (Project 3 & Core B) 

Neris RLS, Kaur A, Gomes AV. Incorrect Molecular Weights due to inaccurate Prestained Protein Molecular Weight Markers that are used for Gel Electrophoresis and Western Blotting. bioRxiv. 2020:2020.04.03.023465. doi: 10.1101/2020.04.03.023465. 

Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. Ponceau S waste: Ponceau S staining for total protein normalization. Analytical biochemistry. 2019;575:44-53. Epub 2019/03/28. doi: 10.1016/j.ab.2019.03.010. PubMed PMID: 30914243; PMCID: PMC6954006. 

Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circulation Arrhythmia and electrophysiology. 2017;10(10). Epub 2017/10/14. doi: 10.1161/circep.117.005267. PubMed PMID: 29025768; PMCID: PMC5662469. 

Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circulation Arrhythmia and electrophysiology. 2016;9(5). Epub 2016/05/11. doi: 10.1161/circep.115.003721. PubMed PMID: 27162031; PMCID: PMC4869994. 

Sirish P, Thai PN, Lee JH, Yang J, Zhang XD, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem cells translational medicine. 2020. Epub 2020/08/14. doi: 10.1002/sctm.20-0143. PubMed PMID: 32790136. (Project 5 & Core A) 

Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton AA. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. Journal of molecular and cellular cardiology. 2016;94:180-188. doi: 10.1016/j.yjmcc.2016.03.019. Epub 2016 Apr 11. PubMed PMID: 27079253.PMCID: PMC4972711 

Tiwari S, Mishra M, Salemi MR, Phinney BS, Newens JL, Gomes AV. Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. Scientific reports. 2020;10(1):3386. doi: 10.1038/s41598-020-60053-y. PubMed PMID: 32099006. 

Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural brain research. 2017;326:69-76. Epub 2017/03/06. doi: 10.1016/j.bbr.2017.02.048. PubMed PMID: 28259677; PMCID: PMC5409858. (Project 5 & Core A)